G protein-coupled receptor signaling pathway [GO_0007186]

The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
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G protein-coupled receptor signaling pathway

ID: GO_0007186

Class

The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.

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Classification

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Alternative Names

Synonym Scope Reference
G-protein coupled receptor signaling pathway via GPCR dimer narrow synonym bf
dimeric G-protein coupled receptor signaling pathway narrow synonym
dimeric G-protein coupled receptor signalling pathway narrow synonym mah
G-protein coupled receptor protein signal transduction exact synonym
G protein coupled receptor protein signaling pathway exact synonym
G protein coupled receptor protein signalling pathway exact synonym
G-protein coupled receptor signalling pathway exact synonym
G-protein-coupled receptor protein signalling pathway exact synonym
GPCR signaling pathway exact synonym
GPCR signalling pathway exact synonym
G-protein coupled receptor protein signaling pathway exact synonym bf

References